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4-Nitrobenzoyl chloride → 2'-[2-(1-Methyl-2-piperidyl)ethyl]-4-nitrobenzanilide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrobenzoyl chloride | HCID 8502 | — |
| 反応物 | 2-(2-Aminophenethyl)-1-methylpiperidine | HCID 11085282 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2'-[2-(1-Methyl-2-piperidyl)ethyl]-4-nitrobenzanilide | HCID 20560086 | — |
反応手順
Reaction of 4-nitrobenzoyl chloride (6.5 g., 0.035 mole) and 2-(o-aminophenethyl)-1-methylpiperidine (6.0 g., 0.0275 mole) in 35 ml. of pyridine according to the method of Example 25 provides 2'-[2-(1-methyl-2-piperidyl)ethyl]-4-nitrobenzanilide. Crystallization from ethyl acetate provides analytically pure material, m.p. 162°-163.5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04064254 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-acce8eb540c44055b2e302906f248ea9 |
| 出典メモ | uspto-grants-1977_12 |