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4-Methylbenzoyl Chloride → 2'-[2-(1-Methyl-2-piperidyl)ethyl]-p-toluanilide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylbenzoyl Chloride | HCID 13405 | — |
| 反応物 | 2-(2-Aminophenethyl)-1-methylpiperidine | HCID 11085282 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2'-[2-(1-Methyl-2-piperidyl)ethyl]-p-toluanilide | HCID 20560077 | — |
反応手順
Reaction of 2-(o-aminophenethyl)-1-methylpiperidine (80 g., 0.036 mole) with p-toluoyl chloride (6.2 g., 0.04 mole) in 50 ml. of pyridine according to the method of Example 25 provides 2'-[2-(1-methyl-2-piperidyl)ethyl]p-toluanilide. Crystallization from isopropyl ether and then from isopropyl alcohol provides 3.9 g., (32%) of analytically pure material, m.p. 90.5°-92° C. (corr.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04064254 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-3f77562955d5417f9a6c43a0fda27edb |
| 出典メモ | uspto-grants-1977_12 |