Diethyl Ether → Tricyclo(3.3.1.13,7)decane-2-ethanamine

HRID 461997ノート

反応式

HRID 461997 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)C.[CH:12]12[CH2:21][CH:16]3[CH2:17][CH:18]([CH2:20][CH:14]([CH2:15]3)[CH:13]1[CH2:22][C:23]#[N:24])[CH2:19]2>O>[CH:12]12[CH2:21][CH:16]3[CH2:17][CH:18]([CH2:20][CH:14]([CH2:15]3)[CH:13]1[CH2:22][CH2:23][NH2:24])[CH2:19]2

参加物

5

反応物 3

HCID 3283Diethyl Ether2 回HCID 12571472HCID 12571472、化合物HCID 21226445Aluminium lithium hydride

生成物 1

HCID 64411Tricyclo(3.3.1.13,7)decane-2-ethanamine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

0.051 Mole of lithium aluminum hydride is dissolved in 200 ml. of anhydrous ethyl ether at 0° C, under nitrogen. 0.0571 Mole of adamant-2-yl acetonitrile in 100 ml. of anhydrous ethyl ether is added dropwise with stirring and the mixture is allowed to warm to room temperature and stirred for one hour. 10 Ml. of water is added dropwise and the mixture then filtered. The filtrate is dried over potassium hydroxide pellets and then filtered. The filtrate is distilled to remove the solvent affording 2-(adamant-2-yl)ethylamine.

後処理

  1. customat 0° C
  2. stirringstirred for one hour
  3. filtrationthe mixture then filtered
  4. dry with materialThe filtrate is dried over potassium hydroxide pellets
  5. filtrationfiltered
  6. distillationThe filtrate is distilled
  7. customto remove the solvent

出典と根拠

ORDレコード
ord-4e6c68a254ed46c19719c17aa1e90ab4
出典データセット
uspto-grants-1977_12
特許番号
US04064258

反応ノート

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