Ethanethiol → 2-chloroethanethiophosphonic acid S-ethyl ester N-monoisopropylamide

HRID 462011ノート

反応式

HRID 462011 の反応式
[CH2:1]([SH:3])[CH3:2].C(N(CC)CC)C.[Cl-].[CH:12]([NH:15][P:16]([CH2:19][CH2:20][Cl:21])(=[O:18])[OH:17])([CH3:14])[CH3:13]>C1C=CC=CC=1>[CH:12]([NH-:15])([CH3:14])[CH3:13].[CH2:1]([S:3][P:16]([CH2:19][CH2:20][Cl:21])(=[O:17])[OH:18])[CH3:2]

参加物

5

反応物 3

HCID 6343EthanethiolHCID 8471TriethylamineHCID 867353082-chloroethanephosphonic acid N-monoisopropylamide chloride

生成物 1

HCID 867353102-chloroethanethiophosphonic acid S-ethyl ester N-monoisopropylamide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

13 g (0.2 mole) ethylmercaptan and 20 g (0.2 mole) triethylamine are added to 41 g (0.2 mole) 2-chloroethanephosphonic acid N-monoisopropylamide chloride in 100 ml benzene. Stirring was afterwards effected for 2 hours at 40° C; the salts were then filtered off with suction, the reaction solution was washed with water, and drying with sodium sulfate was carried out. After the solvent had been drawn off, there remained behind a crystalline residue, m.p. 51° C, yield: 15 g (33%) 2-chloroethanethiophosphonic acid S-ethyl ester N-monoisopropylamide.

後処理

  1. filtrationthe salts were then filtered off with suction
  2. washthe reaction solution was washed with water
  3. dry with materialdrying with sodium sulfate

出典と根拠

ORDレコード
ord-f7e0b7a378554beaa6617603c1906cbe
出典データセット
uspto-grants-1977_12
特許番号
US04065288

反応ノート

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