2-Pyridone → 3-(3-Chlorophenyl)-5-(4-chlorophenyl)-1-methylpiperidin-4-one

HRID 462015ノート

反応式

HRID 462015 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:13](=[O:14])[C:12]([C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)=[CH:11][N:10]([CH3:22])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.N1C=CC=CC1=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CC(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13](=[O:14])[CH:12]([C:15]3[CH:16]=[CH:17][C:18]([Cl:21])=[CH:19][CH:20]=3)[CH2:11][N:10]([CH3:22])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 88712-PyridoneHCID 128792353-(3-Chlorophenyl)-5-(4-chlorophenyl)-1-methylpyridin-4(1H)-oneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 203170023-(3-Chlorophenyl)-5-(4-chlorophenyl)-1-methylpiperidin-4-one

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A 10 g. portion of 3-(3-chlorophenyl)-5-(4-chlorophenyl)-1-methyl-4(1H)-pyridinone was made from 33.6 g. of the corresponding 2-propanone by the procedures of Examples 1-3. The pyridinone was reduced with lithium aluminum hydride and the reaction mixture was separated by chromatography as described in the examples above. The products of Examples 15 and 16 were obtained as a mixture containing both, combined yield 2.1 g., m.p. 125.5°.

後処理

  1. customthe reaction mixture was separated by chromatography

出典と根拠

ORDレコード
ord-558f29a58adc4b258d6bd1bcf92e38c8
出典データセット
uspto-grants-1977_12
特許番号
US04065290

反応ノート

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