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Nitric Acid → 4-hydroxy-3-nitro-1-phenylquinolin-2(1H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | 4-Hydroxy-1-phenyl-1,2-dihydroquinolin-2-one | HCID 54676161 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-hydroxy-3-nitro-1-phenylquinolin-2(1H)-one | HCID 54683888 | — |
反応手順
A solution of 4-hydroxy-1-phenyl carbostyril (2.20g.; 0.0093 mole) in glacial acetic acid (10 ml.) was treated rapidly with concentrated nitric acid (2.5 ml. d 1.42) and the mixture heated on a steam bath for 21/2 mins. The red solution deposited a dark yellow solid on cooling which, after dilution with ethanol, was filtered off and washed well with ethanol, m.p. (AcOH -- EtOH) 167° - 169° C. (Found; C, 64.13; H, 3.70; N, 9.85; C15H10N2O4 requires; C, 63.83; H, 3.57; N, 9.92%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04065457 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-a69f5488a0de4c33a7336ae511963b3d |
| 出典メモ | uspto-grants-1977_12 |