1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide → 5,7,8,9-tetrahydro-6H-[1,3]dioxolo[4,5-h][3]benzazepin-6-one

関与物質

反応手順

Similarly, 0.005 moles (1.3 grams) of 6-(2-aminoethyl)-4,5-methylenedioxy phenyl-acetic acid hydrochloride were dissolved in 15 ml of water and to this solution was added 2.12 grams of 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide methotoluenesulfonate in 20 ml of water. After 2 hours at room temperature the precipitate that had formed was filtered off, washed and dried to yield 1,3,4,5-tetrahydro-7,8-methylenedioxy-2H-3-benzazepin-2-one, m.p. 236°-237°. After recrystallization from ether the product melted at 238°-239°.

情報源と証拠