化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Anhydride → Nitric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Isosorbide | HCID 12597 | — |
| 反応物 | Isosorbide 2-mononitrate | HCID 62989 | — |
| 生成物 | Nitric Acid | HCID 944 | — |
| 生成物 | Acetic Anhydride | HCID 7918 | — |
反応手順
The following process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate is described: acylating 1,4:3,6-dianhydro-D-glucitol with 0.5 to 1.5 molar equivalents of acetic anhydride in the presence of an acid catalyst, nitrating the product so obtained with a mixture of nitric acid and acetic anhydride, hydrolyzing the product so obtained in the presence of an inorganic base and isolating 1,4:3,6-dianhydro-D-glucitol 2-nitrate. The 1,4:3,6-dianhydro-D-glucitol 2-nitrate is useful as a coronary vasodilator.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04065488 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-7f6d1bd3a7d64f5cabbc56f6cd46a244 |
| 出典メモ | uspto-grants-1977_12 |