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Dimethyl Sulfate → Methyl 1-methoxy-4-bromo-2-naphthoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfate | HCID 6497 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid | HCID 289393 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Methyl 1-methoxy-4-bromo-2-naphthoate | HCID 12084039 | 78.6% |
反応手順
A mixture of 4-bromo-1-hydroxy-2-naphthoic acid (compound 67, 24.7 g, 92.2 mmol), dimethyl sulfate (21.8 mL, 231 mmol), and K2CO3 (31.9 g, 231 mmol) in acetone (200 mL) was refluxed overnight. The solid was filtered, and the filtrate was condensed to give a solid residue, which was recrystallized from EtOAc/hexanes to afford the title compound (21.4 g, 78%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541380B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-b799a19433b34ef4a7ca626fb9a3a390 |
| 出典メモ | uspto-grants-2013_09 |