1-[3-(Dimethylamino)propyl]piperazine → 2-{2-[4-(3-Dimethylaminopropyl)-1-piperazinyl]-5-thiadiazolyl}-1-methyl-5-nitroimidazole

HRID 462236

反応式

HRID 462236 の反応式
Cl[N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1.[CH3:16][N:17]([CH3:27])[CH2:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>O1CCOCC1>[CH3:27][N:17]([CH3:16])[CH2:18][CH2:19][CH2:20][N:21]1[CH2:22][CH2:23][N:24]([N:2]2[NH:6][CH:5]=[C:4]([C:7]3[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=3)[S:3]2)[CH2:25][CH2:26]1

参加物

4

反応物 2

HCID 27362341-[3-(Dimethylamino)propyl]piperazineHCID 213908012-(2-Chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole

生成物 1

HCID 213908032-{2-[4-(3-Dimethylaminopropyl)-1-piperazinyl]-5-thiadiazolyl}-1-methyl-5-nitroimidazole

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A solution of 2-(2-chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole in 200 ml. of dioxane is treated with 5.1 g. of 1-(3-dimethylaminopropyl)piperazine, and the mixture stirred at room temperature for 18 hours. The precipitate is collected, dissolved in 100 ml. of water, made alkaline with sodium hydroxide solution, and then extracted with 500 ml. of chloroform. The chloroform extract is dried and the solvent removed under reduced pressure. The yellow residue is recrystallized from 100 ml. of ethanol to give 2.9 g. of product, melting at 174°-175° C.

後処理

  1. customThe precipitate is collected
  2. dissolutiondissolved in 100 ml
  3. extractionextracted with 500 ml
  4. extractionThe chloroform extract
  5. customis dried
  6. customthe solvent removed under reduced pressure
  7. customThe yellow residue is recrystallized from 100 ml
  8. customof ethanol to give 2.9 g

出典と根拠

ORDレコード
ord-c2bace9bd66849a0a94a28186d1478c3
出典データセット
uspto-grants-1977_12
特許番号
US04065567

関連ノート

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