戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 462237作成日：2026年10月26日

1-(Thiazol-2-yl)piperazine → 2-{2-[4-(2-Thiazolyl)-1-piperazinyl]-5-thiadiazolyl]-1-methyl-5-nitroimidazole

https://huagongshe.com/reaction/462237

反応式

関与物質

役割名称HCID仕込み量
反応物1-(Thiazol-2-yl)piperazineHCID 911806—
反応物1-[3-(Dimethylamino)propyl]piperazineHCID 2736234—
反応物2-{2-[4-(3-Dimethylaminopropyl)-1-piperazinyl]-5-thiadiazolyl}-1-methyl-5-nitroimidazoleHCID 21390803—
生成物2-{2-[4-(2-Thiazolyl)-1-piperazinyl]-5-thiadiazolyl]-1-methyl-5-nitroimidazoleHCID 21390853—

反応手順

The preparation of the subject compound is carried out essentially as described for the 2-[4-(3-dimethylaminopropyl)-1-piperazinyl] derivative (Example 35), an equivalent of 1-(2-thiazolyl)piperazine replacing the 1-(3-dimethylaminopropyl)piperazine. After recrystallization from 2-methoxyethanol, the pure compound melts at 297°-300° C.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US04065567
出典データセットuspto-grants-1977_12
ORD IDord-10dfc038fa9d47f89d1562cb38168a32
出典メモuspto-grants-1977_12