関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2,4-Dichlorobenzoic Acid | HCID 5787 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 触媒 | Sulfur | HCID 5362487 | — |
| 溶媒 | Chlorosulfonic acid | HCID 24638 | — |
| 生成物 | 5-Bromo-2,4-dichlorobenzoic acid | HCID 21862565 | 187.5% |
反応手順
To a solution of 2,4-dichlorobenzoic acid (compound 80, 25.0 g, 131 mmol) in chlorosulfonic acid (100 mL) was added bromine (3.4 mL, 65 mmol) and sulfur (0.20 g, 6.6 mmol). The reaction mixture was stirred at 70° C. overnight and then cooled to ambient temperature. The reaction mixture was poured into iced water. The resulting solid was isolated by filtration and dried in vacuo to yield title compound (32.9 g, 93%) as pale brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08541380B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-541340427c5d4696b208240ea8e76d24 |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
