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Benzaldehyde → 3,5-Dibenzylidene-1-(2-phenylethyl)-4-piperidone monohydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | N-Phenethyl-4-piperidinone | HCID 96437 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3,5-Dibenzylidene-1-(2-phenylethyl)-4-piperidone monohydrochloride | HCID 68118837 | — |
反応手順
Twenty-five grams of 1-(2-phenylethyl)-4-piperidone and 38 g of benzaldehyde are reacted in 180 ml of ethanol in the presence of 40 ml of concentrated hydrochloric acid at reflux temperature for about 5 hours and left at room temperature for about 16 hours yielding 25.5 g of material, melting point 217°-220° C, dec. Crystallization from 50 ml of hot dimethylformamide and 100 ml of acetonitrile yields 22 g of the title compound, melting point 225°-227° C, dec.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04065617 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-b0b857edc23e4ecdb0e73d1f4d1d7e60 |
| 出典メモ | uspto-grants-1977_12 |