Methanol → 2-Cyclopropyl-4,6-dimethoxy-1,3,5-triazine
反応式
[CH3:1][O-:2].[Na+].[CH:4]1([C:7]2[N:12]=[C:11](C(Cl)(Cl)Cl)[N:10]=[C:9](C(Cl)(Cl)Cl)[N:8]=2)[CH2:6][CH2:5]1.[CH3:21][OH:22]>>[CH:4]1([C:7]2[N:12]=[C:11]([O:2][CH3:1])[N:10]=[C:9]([O:22][CH3:21])[N:8]=2)[CH2:6][CH2:5]1参加物
4
実験手順
8.1 g of sodium methylate are added to a solution of 71.2 g of 2-cyclopropyl-4,6-bis-(trichloromethyl)-1,3,5-triazine in 200 ml of methanol, and stirring is maintained for 5 hours at room temperature. The solution is then evaporated to dryness, and the residue is stirred up with 200 ml of ether. The resulting suspension is filtered and the filtrate is concentrated by evaporation. The residue crystallises, and is recrystallised from ether/hexane. The yield is 35.7 g of the above triazine, m.p. 68°-70° C.
後処理
- customThe solution is then evaporated to dryness
- stirringthe residue is stirred up with 200 ml of ether
- filtrationThe resulting suspension is filtered
- concentrationthe filtrate is concentrated by evaporation
- customThe residue crystallises
- customis recrystallised from ether/hexane
出典と根拠
- ORDレコード
- ord-3a7416a9435a4d5fb8093b31027fe734
- 出典データセット
- uspto-grants-1985_05
- 特許番号
- US04515626
反応ノート
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