Water → 4-Cyclopropyl-6-methoxy-1,3,5-triazin-2-amine
反応式
[NH2:1][C:2]1[N:7]=[C:6]([CH:8]2[CH2:10][CH2:9]2)[N:5]=[C:4](C(Cl)(Cl)Cl)[N:3]=1.[CH3:15][O-:16].[Na+].O>CO>[NH2:1][C:2]1[N:7]=[C:6]([CH:8]2[CH2:10][CH2:9]2)[N:5]=[C:4]([O:16][CH3:15])[N:3]=1参加物
5
反応条件
- 温度
- 60 °C
実験手順
25.3 g of 2-amino-4-cyclopropyl-6-trichloromethyl-1,3,5-triazine are added to a solution of 10.8 g of sodium methylate in 50 ml of methanol, and the mixture is stirred at 60° C. for 80 minutes. There are added 300 ml of water, and the formed suspension is filtered. The filter residue is suspended twice in 100 ml of acetyl acetate each time, and again filtered. The organic phases are collected, dried over magnesium sulfate and concentrated by evaporation to thus obtain an oil, which crystallises when stirred up in ether. The yield is 6.7 g of the title compound, m.p. 158°-159° C.
後処理
- filtrationthe formed suspension is filtered
- filtrationagain filtered
- customThe organic phases are collected
- dry with materialdried over magnesium sulfate
- concentrationconcentrated by evaporation
- customto thus obtain an oil, which
- customcrystallises when
- stirringstirred up in ether
出典と根拠
- ORDレコード
- ord-702aed28a5ad4b1f81db9fb2b11a1601
- 出典データセット
- uspto-grants-1985_05
- 特許番号
- US04515626
反応ノート
読み込み中…