Diethyl Ether → N,N-Dimethyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarboxamide

HRID 4625ノート

反応式

HRID 4625 の反応式
[CH2:1]([N:3]([CH2:6]C)[CH2:4]C)C.[N:8]1([CH2:14][C:15]2[CH:16]=[C:17]([CH:27]=[CH:28][CH:29]=2)[O:18][CH2:19][CH2:20][CH2:21][NH:22][C:23]([NH:25][NH2:26])=[O:24])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.CC[O:32]CC>>[CH3:1][N:3]([CH3:6])[C:4]([NH:26][NH:25][C:23]([NH:22][CH2:21][CH2:20][CH2:19][O:18][C:17]1[CH:27]=[CH:28][CH:29]=[C:15]([CH2:14][N:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH:16]=1)=[O:24])=[O:32]

参加物

4

反応物 3

HCID 3283Diethyl EtherHCID 8471TriethylamineHCID 13657330N-(3-{3-[(Piperidin-1-yl)methyl]phenoxy}propyl)hydrazinecarboxamide

生成物 1

HCID 13657354N,N-Dimethyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarboxamide

実験手順

0.6 ml (4 mmol) of triethylamine and 0.4 ml (4 mmol) of N,N-dimethyl-carbamide chloride are added to 1.2 g (4 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carboxamide in 20 ml of ether and the reaction mixture is stirred for 12 hours. Solid triethylammonium chloride is filtered off and the filtrate is concentrated by evaporation under vacuum.

後処理

  1. filtrationSolid triethylammonium chloride is filtered off
  2. concentrationthe filtrate is concentrated by evaporation under vacuum

出典と根拠

ORDレコード
ord-d528eaedefc846aebb42fe733e14626e
出典データセット
uspto-grants-1988_02
特許番号
US04727081

反応ノート

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