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Hydrogen Cyanide → 2-(2-Fluoro-4-trifluoromethylphenylamino)-3-methylbutyronitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Cyanide | HCID 768 | — |
| 反応物 | Isobutyraldehyde | HCID 6561 | — |
| 反応物 | 2-Chloro-4-trifluoromethylaniline | HCID 162001 | — |
| 反応物 | 2-Fluoro-4-(trifluoromethyl)aniline | HCID 2737674 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(2-Fluoro-4-trifluoromethylphenylamino)-3-methylbutyronitrile | HCID 20283984 | — |
反応手順
Following the procedure of Example 1, each of 3-chloro-4-aminobenzotrifluoride and 3-fluoro-4-aminobenzotrifluoride is reacted with hydrogen cyanide and isobutyraldehyde, in a neat, initially water-free system, to give the respective nitrile, 2-(2-chloro-4-trifluoro-methylphenylamino)-3-methylbutyronitrile and 2-(2-fluoro-4-trifluoromethylphenylamino)-3-methylbutyronitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04517130 |
| 出典データセット | uspto-grants-1985_05 |
| ORD ID | ord-f4fb8e7036e843d7865338e8ca199b44 |
| 出典メモ | uspto-grants-1985_05 |