BzMePhe → N-Methylphenylalanine
反応式
[C:1]([N:9](C)[C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(C1C=CC=CC=1)=O.[H][H]>C(O)(=O)C.Cl.[C].[Pd]>[NH:9]([CH3:1])[C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1参加物
6
実験手順
A 12.66 g portion of the BzMePhe was dissolved in 120 ml of acetic acid and 47 ml of HCl, and the solution was subjected to hydrogen catalytic reduction (room temperature, 8 hours) with addition of 5.0 g of 10% palladium-carbon catalyst. After separating off the catalyst by filtration, the filtrate was concentrated in vacuo, and the concentrate was recrystallized from ethanol (50 ml)-ether (500 ml) to give 7.93 g of MePhe, yeild 94.1%. M.p. 225° C.
後処理
- customAfter separating off the catalyst
- filtrationby filtration
- concentrationthe filtrate was concentrated in vacuo
- customthe concentrate was recrystallized from ethanol (50 ml)-ether (500 ml)
出典と根拠
- ORDレコード
- ord-e4aa716fb75948f583d68188c191dda6
- 出典データセット
- uspto-grants-1985_05
- 特許番号
- US04517180
反応ノート
読み込み中…