Cyanoacetamide → 6-Methyl-2-oxo-5-propanoyl-1,2-dihydropyridine-3-carbonitrile

HRID 462705

反応式

HRID 462705 の反応式
CN([CH:4]=[C:5]([C:9](=[O:12])[CH2:10][CH3:11])[C:6](=O)[CH3:7])C.[C:13]([CH2:15][C:16]([NH2:18])=[O:17])#[N:14].C[O-].[Na+]>CO>[CH3:7][C:6]1[NH:18][C:16](=[O:17])[C:15](=[CH:4][C:5]=1[C:9](=[O:12])[CH2:10][CH3:11])[C:13]#[N:14]

参加物

5

反応物 3

HCID 7898CyanoacetamideHCID 10942334Sodium MethoxideHCID 540051333-[(Dimethylamino)methylidene]hexane-2,4-dione

生成物 1

HCID 132320386-Methyl-2-oxo-5-propanoyl-1,2-dihydropyridine-3-carbonitrile

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A-2. 1,2-Dihydro-6-methyl-2-oxo-5-(n-propanoyl)nicotinonitrile and 5-acetyl-6-ethyl-1,2-dihydro-2-oxonicotinonitrile--A mixture containing 34 g of 2,4-hexanedione, 50 ml of dimethylformamide and 40 ml of dimethylformamide dimethyl acetal was allowed to stand at room temperature overnight and then concentrated on a rotary evaporator at steam bath temperature to yield, as a liquid, 3-dimethylaminomethylene-2,4-hexanedione. A mixture containing said 3-dimethylaminomethylene-2,4-hexanedione, 300 ml of methanol 25.2 g of cyanoacetamide and 16.2 g of sodium methoxide was refluxed with stirring for 3 hours and then concentrated in vacuo to remove the methanol. The residue was dissolved in 300 ml of warm water and filtered. The filtrate was acidified with acetic acid and the resulting precipitate was collected, washed with water, dried in vacuo at 90°-95° C. and recrystallized from dimethylformamide (75 ml) to yield 7.8 g of 1,2-dihydro-6-methyl-2-oxo-5-(n-propanoyl)nicotinonitrile, m.p. 265°-268° C. with decomposition. The mother liquor was concentrated to dryness and digested with hot methanol and cooled. The separated solid was dried, 20.2 g, and recrystallized from dimethylformamide to yield 9.8 g of finely crystalline material, m.p. 259°-263° C. with decomposition. The NMR spectral data for this compound indicated it to be mostly said 1,2-dihydro-6-methyl-2-oxo-5-(n-propanoyl)nicotinonitrile. The resulting mother liquors were combined and concentrated on a rotary evaporator and the resulting residue was recrystallized from ethanol to yield 20.4 g of solid, m.p. 220°-226° C. The NMR spectral data for this solid indicated it to be a 5:4 mixture of said 1,2-dihydro-6-methyl-2-oxo-5-(n-propanoyl)nicotinonitrile and 5-acetyl-6-ethyl-1,2-dihydro-2-oxonicotinonitrile. Preliminary attempts to separate the two compounds by fractional crystallization were unsuccessful; however, the two compounds should be separable.

後処理

  1. additionA mixture containing
  2. temperaturewas refluxed
  3. concentrationconcentrated in vacuo
  4. customto remove the methanol
  5. dissolutionThe residue was dissolved in 300 ml of warm water
  6. filtrationfiltered
  7. customthe resulting precipitate was collected
  8. washwashed with water
  9. customdried in vacuo at 90°-95° C.
  10. customrecrystallized from dimethylformamide (75 ml)

出典と根拠

ORDレコード
ord-f1fb0c2c1a7e402eaa46b6db41018f0e
出典データセット
uspto-grants-1985_05
特許番号
US04517190

関連ノート

読み込み中…