2-Bromo-4-fluorophenol → 4-(2-bromo-4-fluoro-phenoxy)-3-cyano-N-[1,2,4]thiadiazol-5-ylbenzenesulfonamide

HRID 46281

反応式

HRID 46281 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[OH:9].[C:10]([C:12]1[CH:13]=[C:14]([S:19]([NH:22][C:23]2[S:27][N:26]=[CH:25][N:24]=2)(=[O:21])=[O:20])[CH:15]=[CH:16][C:17]=1F)#[N:11]>>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[O:9][C:17]1[CH:16]=[CH:15][C:14]([S:19]([NH:22][C:23]2[S:27][N:26]=[CH:25][N:24]=2)(=[O:21])=[O:20])=[CH:13][C:12]=1[C:10]#[N:11]

参加物

3

反応物 2

HCID 6054722-Bromo-4-fluorophenolHCID 580423023-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

生成物 1

HCID 594365714-(2-bromo-4-fluoro-phenoxy)-3-cyano-N-[1,2,4]thiadiazol-5-ylbenzenesulfonamide

実験手順

Prepared according to the process of Preparation 51, using 2-bromo-4-fluorophenol and 3-cyano-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (Preparation 65). LCMS Rt=3.01 min MS m/z 284 [MH]+ 1HNMR (d6-DMSO): δ 6.8 (m, 1H), 7.4 (m, 1H), 7.6 (m, 1H), 7.8 (m, 1H), 8.0 (m, 1H), 8.3 (m, 1H), 8.5 (s, 1H).

後処理

  1. customPrepared
  2. customaccording to the process of Preparation 51

出典と根拠

ORDレコード
ord-34a568c8e4a146d19b1970b1aed3a67d
出典データセット
uspto-grants-2013_09
特許番号
US08541588B2

関連ノート

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