Iodine → 2,3-Dichloro-5-iodopyridine
反応式
C([Li])CCC.[I:6]I.Br[C:9]1[CH:10]=[C:11]([Cl:16])[C:12]([Cl:15])=[N:13][CH:14]=1>C(OCC)C.CCCCCC>[Cl:15][C:12]1[C:11]([Cl:16])=[CH:10][C:9]([I:6])=[CH:14][N:13]=1参加物
6
反応条件
- 温度
- -78 °C
実験手順
In one embodiment of the present invention, 5-bromo-2,3-dichloropyridine is dissolved in ethyl ether and cooled to about -78° C. A slight excess molar quantity of n-butyl lithium, dissolved in hexane, is slowly added to the reaction mixture with mild agitation. After about 0.5 hour of stirring, a slight excess molar quantity of I2, dissolved in ethyl ether, is added to reaction mixture with mild agitation. After about 0.5 hour of stirring, the reaction mixture is allowed to warm to room temperature and the 2,3-dichloro-5-iodopyridine is isolated employing standard separatory and purification techniques.
後処理
- additionis slowly added to the reaction mixture with mild agitation
- additionis added to reaction mixture with mild agitation
- stirringAfter about 0.5 hour of stirring
- temperatureto warm to room temperature
出典と根拠
- ORDレコード
- ord-b1b825a7855043d992d3ed1e62d81722
- 出典データセット
- uspto-grants-1985_05
- 特許番号
- US04517368
反応ノート
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