Iodine → 2,3-Dichloro-5-iodopyridine

HRID 462816

反応式

HRID 462816 の反応式
C([Li])CCC.[I:6]I.Br[C:9]1[CH:10]=[C:11]([Cl:16])[C:12]([Cl:15])=[N:13][CH:14]=1>C(OCC)C.CCCCCC>[Cl:15][C:12]1[C:11]([Cl:16])=[CH:10][C:9]([I:6])=[CH:14][N:13]=1

参加物

6

反応物 3

HCID 807IodineHCID 127477605-Bromo-2,3-dichloropyridineHCID 178418339Butyllithium

生成物 1

HCID 218928742,3-Dichloro-5-iodopyridine

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒2 回HCID 8058Hexane溶媒

反応条件

温度
-78 °C

実験手順

In one embodiment of the present invention, 5-bromo-2,3-dichloropyridine is dissolved in ethyl ether and cooled to about -78° C. A slight excess molar quantity of n-butyl lithium, dissolved in hexane, is slowly added to the reaction mixture with mild agitation. After about 0.5 hour of stirring, a slight excess molar quantity of I2, dissolved in ethyl ether, is added to reaction mixture with mild agitation. After about 0.5 hour of stirring, the reaction mixture is allowed to warm to room temperature and the 2,3-dichloro-5-iodopyridine is isolated employing standard separatory and purification techniques.

後処理

  1. additionis slowly added to the reaction mixture with mild agitation
  2. additionis added to reaction mixture with mild agitation
  3. stirringAfter about 0.5 hour of stirring
  4. temperatureto warm to room temperature

出典と根拠

ORDレコード
ord-b1b825a7855043d992d3ed1e62d81722
出典データセット
uspto-grants-1985_05
特許番号
US04517368

関連ノート

読み込み中…