化工社化工社 化学情報印刷レポート · 研究参考用
Pyridine → 2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 2,4-Difluorobenzenesulfonyl Chloride | HCID 2734273 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide | HCID 25038904 | — |
反応手順
To a slurry of 2-aminothiazole (15.08 g, 0.1506 mol) in methylene chloride (100 mL) and pyridine (24 mL, 0.30 mol) was added dropwise over 20 minutes a solution of 2,4-difluorobenzenesulfonyl chloride (10 mL, 0.07 mol) in 10 mL of methylene chloride. After stirring at room temperature for 48 hours the reaction was concentrated and purified by flash column chromatography eluting with hexane/ethyl acetate. LCMS Rt=1.21 minutes MS m/z 277 [MH]+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541588B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-b083043d358544dcbd3734bbd645a5dc |
| 出典メモ | uspto-grants-2013_09 |