関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Glutaric Acid | HCID 743 | — |
| 反応物 | Glyoxylylspermidine | HCID 133564 | — |
| 反応物 | HCID 178478612 | HCID 178478612 | — |
| 反応物 | HCID 178479441 | HCID 178479441 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 178512828 | HCID 178512828 | 37.1% |
反応手順
A mixture of 92.4 mg (0.48 mmole) of 5-guanidinopentanamide hydrochloride, 166.5 mg (0.57 mmole) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 62.8 mg (0.48 mmole) of glutaric acid and 0.1 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, 5 ml of water was added to the reaction mixture which was then purified in a manner similar to that in Example 1 using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 82.5 mg (37.1% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(5-guanidinopentanamido)-2-hydroxyethanamide trihydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04518532 |
|---|
| 出典データセット | uspto-grants-1985_05 |
|---|
| ORD ID | ord-7ecb292195b241efa5d2b94bfa3b0af0 |
|---|
| 出典メモ | uspto-grants-1985_05 |
|---|
