反応式
Cl.N(CCCCCC(N)=O)C(N)=N.Cl.Cl.NCCCNCCCCNC(=O)C(O)O.C(O)(=O)CCCC(O)=O.Cl.Cl.Cl.[NH2:43][CH2:44][CH2:45][CH2:46][NH:47][CH2:48][CH2:49][CH2:50][CH2:51][NH:52][C:53](=[O:68])[CH:54]([NH:56][C:57](=[O:67])[CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][NH:63][C:64]([NH2:66])=[NH:65])[OH:55]>O>[NH2:43][CH2:44][CH2:45][CH2:46][NH:47][CH2:48][CH2:49][CH2:50][CH2:51][NH:52][C:53](=[O:68])[CH:54]([NH:56][C:57](=[O:67])[CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][NH:63][C:64]([NH2:66])=[NH:65])[OH:55]参加物
6
反応条件
- 温度
- 60 °C
実験手順
A mixture of 446 mg (2.14 mmoles) of 6-guanidinohexanamide hydrochloride, 750 mg (2.57 mmoles) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 283 mg (2.14 mmoles) of glutaric acid and 0.45 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, 5 ml of water was added to the reaction mixture and the resulting mixture was purified in a manner similar to that in Example 1, using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 459 mg (44% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(6-guanidinohexanamido)-2-hydroxyethanamide trihydrochloride.
後処理
- additionwas added to the reaction mixture
- customthe resulting mixture was purified in a manner similar to that in Example 1
出典と根拠
- ORDレコード
- ord-5428e93f3522409ab46bd8ae87e26d73
- 出典データセット
- uspto-grants-1985_05
- 特許番号
- US04518532
関連ノート
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