反応式
Cl.N(CCCCCCC(N)=O)C(N)=N.Cl.Cl.NCCCNCCCCNC(=O)C(O)O.C(O)(=O)CCCC(O)=O.Cl.Cl.Cl.[NH2:44][CH2:45][CH2:46][CH2:47][NH:48][CH2:49][CH2:50][CH2:51][CH2:52][NH:53][C:54](=[O:70])[CH:55]([NH:57][C:58](=[O:69])[CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][NH:65][C:66]([NH2:68])=[NH:67])[OH:56]>O>[NH2:44][CH2:45][CH2:46][CH2:47][NH:48][CH2:49][CH2:50][CH2:51][CH2:52][NH:53][C:54](=[O:70])[CH:55]([NH:57][C:58](=[O:69])[CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][NH:65][C:66]([NH2:68])=[NH:67])[OH:56]参加物
6
反応条件
- 温度
- 60 °C
実験手順
A mixture of 360 mg (1.62 mmoles) of 7-guanidinoheptanamide hydrochloride, 568 mg (1.94 mmoles) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 214 mg (1.62 mmoles) of glutaric acid and 0.36 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, 5 ml of water was added to the reaction mixture and the resulting mixture was purified in a manner similar to that in Example 1, using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 317 mg (39% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(7-guanidinoheptanamido)-2-hydroxyethanamide trihydrochloride.
後処理
- additionwas added to the reaction mixture
- customthe resulting mixture was purified in a manner similar to that in Example 1
出典と根拠
- ORDレコード
- ord-89bca08c32784ea2b7a91ac5492d07d9
- 出典データセット
- uspto-grants-1985_05
- 特許番号
- US04518532
関連ノート
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