関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Glutaric Acid | HCID 743 | — |
| 反応物 | Glyoxylylspermidine | HCID 133564 | — |
| 反応物 | HCID 178478608 | HCID 178478608 | — |
| 反応物 | HCID 178479428 | HCID 178479428 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 178512807 | HCID 178512807 | 46.5% |
反応手順
A mixture of 234.5 mg (1.06 mmoles) of 7-guanidino-2-heptenamide hydrochloride, 372.3 mg (1.27 mmoles) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 140.4 mg (1.06 mmoles) of glutaric acid and 0.2 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, the reaction mixture was purified in a manner similar to that in Example 1 using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 244.6 mg (46.5% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(7-guanidino-2-heptenamido)-2-hydroxyethanamide trihydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04518532 |
|---|
| 出典データセット | uspto-grants-1985_05 |
|---|
| ORD ID | ord-7b5e551b8e8b4ac4a80b1dc4e1c7555c |
|---|
| 出典メモ | uspto-grants-1985_05 |
|---|
