Glutaric Acid → HCID 178478607、化合物

HRID 462915

反応式

HRID 462915 の反応式
[ClH:1].[NH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[CH:12][C:13]([NH2:15])=[O:14])[C:3]([NH2:5])=[NH:4].Cl.Cl.[NH2:18][CH2:19][CH2:20][CH2:21][NH:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][C:28](=[O:32])[CH:29](O)[OH:30].C(O)(=O)CCCC(O)=O>O>[ClH:1].[ClH:1].[ClH:1].[NH2:18][CH2:19][CH2:20][CH2:21][NH:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][C:28](=[O:32])[CH:29]([NH:15][C:13](=[O:14])[CH:12]=[CH:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][NH:2][C:3]([NH2:5])=[NH:4])[OH:30]

参加物

5

反応物 3

HCID 743Glutaric AcidHCID 133564GlyoxylylspermidineHCID 178479426HCID 178479426、化合物

生成物 1

HCID 178478607HCID 178478607、化合物収率 87.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

A mixture of 202.4 mg (0.86 mmole) of 8-guanidino-2-octenamide hydrochloride, 302.4 mg (1.04 mmoles) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 113.9 mg (0.86 mmole) of glutaric acid and 0.2 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, the reaction mixture was purified in a manner similar to that in Example 1 using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 128.3 mg (29.2% yield) of N-[4-(3-aminopropyl)aminobutyl]-2-(8-guanidino-2-octenamido)-2-hydroxyethanamide trihydrochloride.

後処理

  1. customAfter completion of the reaction
  2. customthe reaction mixture was purified in a manner similar to that in Example 1 using CM-Sephadex®

出典と根拠

ORDレコード
ord-6c1e68a718024487ad77d8396a8eeef4
出典データセット
uspto-grants-1985_05
特許番号
US04518532

関連ノート

読み込み中…