関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Glutaric Acid | HCID 743 | — |
| 反応物 | Glyoxylylspermidine | HCID 133564 | — |
| 反応物 | HCID 178478605 | HCID 178478605 | — |
| 反応物 | HCID 178479425 | HCID 178479425 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-[4-(3-aminopropyl)aminobutyl]-2-(9-guanidino-2-nonenamido)-2-hydroxyethanamide | HCID 178512796 | 38.9% |
反応手順
A mixture of 206.2 mg (0.84 mmole) of 9-guanidino-2-nonenamide hydrochloride, 291.0 mg (1.00 mmole) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 109.6 mg (0.84 mmole) of glutaric acid and 0.2 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, the reaction mixture was purified in a manner similar to that in Example 1 using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 135.0 mg (31.1% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(9-guanidino-2-nonenamido-2-hydroxyethanamide trihydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04518532 |
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| 出典データセット | uspto-grants-1985_05 |
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| ORD ID | ord-dc615805a55a42cf8a30f6d2f2018da6 |
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| 出典メモ | uspto-grants-1985_05 |
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