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Gamma-Aminobutyric Acid → 4-(((Benzyloxy)carbonyl)amino)butanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Gamma-Aminobutyric Acid | HCID 119 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-(((Benzyloxy)carbonyl)amino)butanoic acid | HCID 21184 | — |
反応手順
A solution of 5.16 g (0.103 mmol) of benzyl chloroformate in 100 ml of dry dioxan is added dropwise over a period of 30 minutes to a solution of 10.60 g (0.1 mmol) of 4-aminobutyric acid in 300 ml of 1N sodium hydroxide solution in an ice bath. The reaction mixture is stirred for 30 minutes at room temperature, acidified with 2N hydrochloric acid and extracted with methylene chloride. The organic phase is dried with sodium sulphate and concentrated in vacuo. The 4-benzyloxycarbonylaminobutyric acid obtained is recrystallised from ethyl acetate, methylene chloride and hexane; melting point 61°-62°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04518533 |
| 出典データセット | uspto-grants-1985_05 |
| ORD ID | ord-ea61c5728c944f2aa507a1acd9a10a35 |
| 出典メモ | uspto-grants-1985_05 |