Acetyl chloride → 2-(N-Acetyl-piperazino)-8-benzylthio-4-morpholino-pyrimido-[5,4-d]-pyrimidine

HRID 462945

反応式

HRID 462945 の反応式
[CH2:1]([S:8][C:9]1[C:14]2[N:15]=[C:16]([N:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31](Cl)(=[O:33])[CH3:32]>CC(C)=O>[C:31]([N:28]1[CH2:27][CH2:26][N:25]([C:16]2[N:17]=[C:18]([N:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)[C:13]3[N:12]=[CH:11][N:10]=[C:9]([S:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[C:14]=3[N:15]=2)[CH2:30][CH2:29]1)(=[O:33])[CH3:32]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 132466RX-RA 69

生成物 1

HCID 201501312-(N-Acetyl-piperazino)-8-benzylthio-4-morpholino-pyrimido-[5,4-d]-pyrimidine

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A suspension of 2.1 gm (0.005 mol) of 8-benzylthio-4-morpholino-2-piperazino-pyrimido-[5,4-d]-pyrimidine (m.p.: 191°-193° C.) in 150 ml of acetone was refluxed for 30 minutes after addition of 0.8 gm (0.01 mol) of acetyl chloride. The solvent was then evaporated in vacuo, and the residue was taken up in approximately 200 ml of water. The reaction product was suction-filtered off, washed with water and dried.

後処理

  1. temperaturewas refluxed for 30 minutes
  2. customThe solvent was then evaporated in vacuo
  3. filtrationThe reaction product was suction-filtered off
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-03e252ba4b3c4480bdfd09269861dd62
出典データセット
uspto-grants-1985_05
特許番号
US04518596

関連ノート

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