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5-Methoxy-2-nitrobenzaldehyde → (2-Amino-5-methoxyphenyl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Methoxy-2-nitrobenzaldehyde | HCID 230371 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (2-Amino-5-methoxyphenyl)methanol | HCID 13756678 | — |
反応手順
A quantity of 181.2 gm (1 mol) of 5-methoxy-2-nitrobenzaldehyde (prepared by methylation of 2-nitro-5-hydroxy-benzaldehyde with methyl iodide/potassium tert.-butoxide in dimethylsulfoxide) is dissolved in 1.8 liters of methanol, mixed with 50 gm of Raney nickel, and hydrogenated at ambient temperature and at 5 bar. After ten hours, the hydrogen uptake has ended. The catalyst is removed by suction filtration, and the methanol is distilled off.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04518597 |
| 出典データセット | uspto-grants-1985_05 |
| ORD ID | ord-03aee2ce438b454aa75f4a46a9749cfa |
| 出典メモ | uspto-grants-1985_05 |