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2,4,5-Trifluorobenzenesulfonyl chloride → N-(5-chloro-1,3-thiazol-2-yl)-N-(2,4-dimethoxybenzyl)-2,4,5-trifluorobenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4,5-Trifluorobenzenesulfonyl chloride | HCID 2776979 | — |
| 反応物 | 5-chloro-N-(2,4-dimethoxybenzyl)-1,3-thiazol-2-amine | HCID 57732151 | — |
| 生成物 | N-(5-chloro-1,3-thiazol-2-yl)-N-(2,4-dimethoxybenzyl)-2,4,5-trifluorobenzenesulfonamide | HCID 59436501 | — |
反応手順
Prepared according to Preparation 333 using 5-chloro-N-(2,4-dimethoxybenzyl)-1,3-thiazol-2-amine (Preparation 208) and 2,4,5-trifluorobenzenesulfonyl chloride. Purification using ISCO™ (12 g SiO2) eluting with ethyl acetate:heptane (gradient 0:1 to 3:7, by volume) afforded the title compound as an orange solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541588B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-ffe806c09b414896b643a0622bdf64fb |
| 出典メモ | uspto-grants-2013_09 |