Benzeneacetamide,a-hydroxy-n-(2-phenylethyl)- → N-phenethyl phenyl-alpha-(o-acetylmandeloyloxy)acetamide

関与物質

反応手順

N-phenethyl mandelic amide 51 g is dissolved in 150 ml of pyridine, and o-acetylmandelic acid chloride 60 ml is added with stirring. Exothermic acylation takes place immediately and the stirring is continued for 5 hours. The reaction mixture is mixed with 1 liter of cold 0.2N HCL. The sticky solid thus formed is extracted with 300 ml of chloroform, washed with 400 ml of 5% sodium bicarbonate and is dried over anhydrous sodium sulfate. On evaporation of chloroform a syrupy product 98 g is obtained.

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