化工社化工社 化学情報印刷レポート · 研究参考用
Ammonium Chloride → 4'-Chloro-3-phenylpropiophenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Benzenepropanoyl chloride | HCID 64801 | — |
| 反応物 | HCID 178478191 | HCID 178478191 | — |
| 触媒 | Cadmium chloride, dihydrate | HCID 24633 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 4'-Chloro-3-phenylpropiophenone | HCID 247344 | 58% |
反応手順
Phenylpropionyl chloride (33.7 g) in benzene was added dropwise to a stirred mixture of 4-chlorophenyl magnesium bromide (derived from 38 g of 4-chlorobromobenzene) and cadmium chloride (37 g) in benzene at 0°. The mixture was stirred at room temperature for 6 hours and aqueous ammonium chloride solution then added. Ether extraction yielded p-chlorophenyl phenylethyl ketone (25 g) m.p. 78°-79°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04520007 |
| 出典データセット | uspto-grants-1985_05 |
| ORD ID | ord-61dbe1b7ada641c0b901f2e585d9aef7 |
| 出典メモ | uspto-grants-1985_05 |