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4-Chloro-1,2-dinitrobenzene → ethyl P-methyl-2-nitro-5-chlorophenylphosphinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-1,2-dinitrobenzene | HCID 33097 | — |
| 反応物 | Diethyl methylphosphonite | HCID 85063 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | ethyl P-methyl-2-nitro-5-chlorophenylphosphinate | HCID 53860251 | — |
反応手順
To 4-chloro-1,2-dinitrobenzene (13.2 g, 65.0 mmol) dissolved in acetonitrile (150 ml) is added, dropwise, diethyl methylphosphonite (16.0 g, 117.6 mmol). The mixture is stirred at RT for 20 hours, after which it is concentrated. The crude product is purified by column chromatography (developing with 50% ethyl acetate/hexane) to yield ethyl P-methyl-2-nitro-5-chlorophenylphosphinate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04520197 |
| 出典データセット | uspto-grants-1985_05 |
| ORD ID | ord-cd5e6dca7b5048fab9a1583e2647bcfa |
| 出典メモ | uspto-grants-1985_05 |