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Ammonium Chloride → 4-(2-Chloro-4-trifluoromethylphenoxy)-2-aminoaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Benzene, 2-chloro-1-(3,4-dinitrophenoxy)-4-(trifluoromethyl)- | HCID 156238 | — |
| 触媒 | Iron | HCID 23925 | — |
| 溶媒 | Water ethanol | HCID 19096565 | — |
| 生成物 | 4-(2-Chloro-4-trifluoromethylphenoxy)-2-aminoaniline | HCID 13503948 | — |
反応手順
A mixture of 4-(2-chloro-4-trifluoromethylphenoxy)-1,2-dinitrobenzene (2.1 g, 5.8 mmol) and ammonium chloride (6.2 g, 116.0 mmol) is heated in ethanol/water (40 ml/20 ml) to 70°. Iron powder (3.2 g, 58.0 mmol) is added in small portions over 15 minutes, and the mixture is then heated under reflux for 2 hours. The reaction is filtered through celite and stripped. The residue is taken up in ether, washed with water, dried and stripped to give 4-(2-chloro-4-trifluoromethylphenoxy)-2-aminoaniline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04544400 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-5de599c9e66a450487b437f2c6acaf5e |
| 出典メモ | uspto-grants-1985_10 |