9-Chloroacridine → HCID 178419977、化合物

HRID 463685ノート

反応式

HRID 463685 の反応式
Cl[C:2]1[C:3]2[C:8]([N:9]=[C:10]3[C:15]=1[CH:14]=[CH:13][CH:12]=[CH:11]3)=[CH:7][CH:6]=[CH:5][CH:4]=2.Br.[NH:17]([C:19]1[S:20][CH2:21][CH2:22][N:23]=1)[NH2:18].C([O-])(=O)C.[Na+]>C(O)C>[S:20]1[CH2:21][CH2:22][NH:23][C:19]1=[N:17][N:18]=[C:2]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=2[NH:9][C:10]2[C:15]1=[CH:14][CH:13]=[CH:12][CH:11]=2

参加物

5

反応物 3

HCID 710139-ChloroacridineHCID 517045Sodium AcetateHCID 27743032-Thiazolidinone, hydrazone, hydrobromide

生成物 1

HCID 178419977HCID 178419977、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.0 g of 9-chloroacridine, 0.926 g of 2-hydrazino-2-thiazoline hydrobromide and 0.767 g of anhydrous sodium acetate are dissolved in 100 ml of dry ethanol, heated to boiling under reflux for 2 hours and the red solution is then evaporated in vacuo. The residue is treated with water and the crystalline mass is filtered under suction. After recrystallization from ethanol, there is obtained 9-acridanone (2-thiazolidinylidene)hydrazone of melting point 212°-216° (decomposition).

後処理

  1. temperatureheated
  2. temperatureunder reflux for 2 hours
  3. customthe red solution is then evaporated in vacuo
  4. additionThe residue is treated with water
  5. filtrationthe crystalline mass is filtered under suction
  6. customAfter recrystallization from ethanol

出典と根拠

ORDレコード
ord-c3605f5043f3452c992a8c5d1410e2d7
出典データセット
uspto-grants-1985_10
特許番号
US04544659

反応ノート

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