Chloroacetaldehyde → 10-Methyl-9-[2-(1,3-thiazol-2-yl)hydrazinylidene]-9,10-dihydroacridine--hydrogen chloride (1/1)

HRID 463691ノート

反応式

HRID 463691 の反応式
[CH3:1][N:2]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[N:16][NH:17][C:18]([NH2:20])=[S:19])[C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.[Cl:21][CH2:22][CH:23]=O>CO>[ClH:21].[S:19]1[CH:23]=[CH:22][N:20]=[C:18]1[NH:17][N:16]=[C:9]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[N:2]([CH3:1])[C:3]2[C:8]1=[CH:7][CH:6]=[CH:5][CH:4]=2

参加物

4

反応物 2

HCID 33ChloroacetaldehydeHCID 5201653HCID 5201653、化合物

生成物 1

HCID 2483272110-Methyl-9-[2-(1,3-thiazol-2-yl)hydrazinylidene]-9,10-dihydroacridine--hydrogen chloride (1/1)

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1.9 g of 10-methyl-9acridanone thiosemicarbazone are suspended in 100 ml of methanol and stirred at 50° for 6 hours with 1.73 ml of chloroacetaldehyde (50percent aqueous solution). The mixture is concentrated, the crystalline product is filtered and washed successively with ethanol, water, ethanol and ether. There is obtained 10-methyl-9-acridanone (2-thiazolyl)hydrazone hydrochloride of melting point 224°-225° (decomposition).

後処理

  1. concentrationThe mixture is concentrated
  2. filtrationthe crystalline product is filtered
  3. washwashed successively with ethanol, water, ethanol and ether

出典と根拠

ORDレコード
ord-aa47c8a0a0c044e287f215bea23de30f
出典データセット
uspto-grants-1985_10
特許番号
US04544659

反応ノート

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