Dibenzylamine → 2-[bis(phenylmethyl)amino]-N-(2-methoxyphenyl)acetamide

HRID 463719ノート

反応式

HRID 463719 の反応式
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH3:13])=[O:4].[CH2:14]([NH:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[C:15]1([CH2:14][N:21]([CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:2][C:3]([NH:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[O:12][CH3:13])=[O:4])[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

参加物

4

反応物 2

HCID 7656DibenzylamineHCID 416472-Chloro-N-(2-methoxyphenyl)acetamide

生成物 1

HCID 135605532-[bis(phenylmethyl)amino]-N-(2-methoxyphenyl)acetamide収率 82.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a stirred solution of 28.1 g of 2-chloro-N-(2-methoxyphenyl)acetamide (C.A. 50, 8730i) in 200 ml toluene was added 58.3 g of dibenzylamine and refluxed for 48 hours. After separation of dibenzylamine hydrochloride, the solvent was removed from the reaction mixture. Crystallization of the residue from isopropylether gave 41.9 g colorless crystals of 2-[bis(phenylmethyl)amino]-N-(2-methoxyphenyl)acetamide, mp 92°-94°.

後処理

  1. temperaturerefluxed for 48 hours
  2. customAfter separation of dibenzylamine hydrochloride
  3. customthe solvent was removed from the reaction mixture
  4. customCrystallization of the residue from isopropylether

出典と根拠

ORDレコード
ord-c24279feb3d043638f127fce00c6df15
出典データセット
uspto-grants-1985_10
特許番号
US04544657

反応ノート

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