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Selenium Dioxide → Ethyl 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Selenium Dioxide | HCID 24007 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | Ethyl 2-methanesulfonamidothiazol-4-ylacetate | HCID 3145078 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Ethyl 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylate | HCID 19978726 | — |
反応手順
A mixture of selenium dioxide (11.1 g.), dioxane (250 ml.) and water (5 ml.) was stirred for 15 minutes at 110° to 115° C. to give yellow solution. Ethyl 2-(2-mesylamino-1,3-thiazol-4-yl)acetate (26.4 g) was added thereto with stirring at the same temperature. After stirring for 1 hour, the reaction mixture was decanted with heating and cooled to precipitate yellow crystals. The crystals were collected by filtration, washed with dioxane and ether and dried to give ethyl 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylate (23.5 g.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04544653 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-d1da65eadd1c4c1196592e17b12e83d8 |
| 出典メモ | uspto-grants-1985_10 |