化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 4-Methoxybenzenecarbothioamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Methoxybenzonitrile | HCID 70129 | — |
| 反応物 | Thioacetamide | HCID 2723949 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Methoxybenzenecarbothioamide | HCID 736827 | 75.4% |
反応手順
A mixture of 53.26 g of anisonitrile and 60.10 g of thioacetamide in 600 ml of dimethylformamide was saturated with dry hydrogen chloride gas while being cooled in an ice bath. The mixture was then distilled on an oil bath at 100° C. After the liquid had been removed, aqueous sodium bicarbonate was added and the solid was collected and recrystallized from toluene, giving 50.47 g of 4-methoxythiobenzamide as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04544759 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-e79458266d034204a700be91ab1937be |
| 出典メモ | uspto-grants-1985_10 |