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Nitric Acid → 4-Methyl-3-nitrobenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | p-Tolunitrile | HCID 7724 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | 4-Methyl-3-nitrobenzonitrile | HCID 589333 | — |
反応手順
With stirring, concentrated H2SO4 (205 ml) was cooled to 5° C. Keeping the temperature below 20° C., concentrated HNO3 (85 ml) was added dropwise. Keeping the temperature below 40° C., p-tolunitrile (96 ml) was then added dropwise. After stirring 10 minutes, the reaction mixture was quenched onto 3 kilograms ice, granulated and filtered to yield title product: 120.5 g; m.p. 102°-104°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04546113 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-dea54de7906347e2b8dfc789459cd8c0 |
| 出典メモ | uspto-grants-1985_10 |