関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Amino-4-methoxy-6-methyl-1,3,5-triazine | HCID 15466 | — |
| 反応物 | Benzoic acid, 2-(chlorosulfonyl)-, methyl ester | HCID 117830 | — |
| 反応物 | Sodium Cyanate | HCID 517096 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 溶媒 | Sodium Bicarbonate | HCID 516892 | — |
| 生成物 | Metsulfuron-methyl | HCID 52999 | 55% |
反応手順
A slurry of 10.0 grams (0.042 moles) of 2-carbomethoxybenzenesulfonyl chloride, 5.0 grams (0.0357 moles) 4-methoxy-6-methyl-1,3,5-triazin-2-amine and 6.0 grams (0.092 moles) sodium cyanate in 60 ml N-methylpyrrolidinone was stirred 2 hours at 80° C. The reaction was cooled to 25° C., diluted with 200 ml saturated sodium bicarbonate solution, and filtered. The filtrate was acidified with dilute hydrochloric acid and the product was collected by filtration and dried to give the title compound in 55% yield. The IR spectrum of the title compound was identical to that of an authentic sample prepared as taught in U.S. Pat. No. 4,383,113.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04546179 |
|---|
| 出典データセット | uspto-grants-1985_10 |
|---|
| ORD ID | ord-b7c299a9824f4439972a45dd4673639e |
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| 出典メモ | uspto-grants-1985_10 |
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