化工社化工社 化学情報印刷レポート · 研究参考用
Bromine → 3-Bromo-5-(trifluoromethyl)pyridin-2(1H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 2-Hydroxy-5-(trifluoromethyl)pyridine | HCID 147443 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-Bromo-5-(trifluoromethyl)pyridin-2(1H)-one | HCID 13491775 | 75.8% |
反応手順
0.4 g of 5-trifluoromethyl-2-pyridone was dissolved in 10 ml of acetic acid, and 0.4 g of bromine was added to the solution which was subsequently reacted for 4 hours while stirring. After completion of the reaction, the acetic acid was distilled off, and recrystallization was carried out from a mixed solvent of methylene chloride and n-hexane to obtain 0.45 g of the titled compound having a melting point of 162° to 165° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04546191 |
| 出典データセット | uspto-grants-1985_10 |
| ORD ID | ord-e3812815ec9d471faee9967cbaf14091 |
| 出典メモ | uspto-grants-1985_10 |