Ethyl orthoformate → 4-Chloro[1,2,4]triazolo[4,3-a]quinoxaline

HRID 464280

反応式

HRID 464280 の反応式
[Cl:1][C:2]1[C:11]([NH:12][NH2:13])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH:14](OCC)(OCC)OCC>>[Cl:1][C:2]1[C:11]2[N:10]([CH:14]=[N:13][N:12]=2)[C:9]2[C:4]([N:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2

参加物

3

反応物 2

HCID 31214Ethyl orthoformateHCID 36588202-Chloro-3-hydrazinoquinoxaline

生成物 1

HCID 11261184-Chloro[1,2,4]triazolo[4,3-a]quinoxaline収率 94%

実験手順

2-Chloro-3-hydrazinoquinoxaline (9.0 g., 0.046 mole) the product of Example 1, was stirred with triethyl orthoformate (90 ml.) at 100° C. for one hour. The mixture was cooled to room temperature and the solid precipitate was collected by filtration and washed with cyclohexane and dried to afford 8.8 g. (94% yield) of 4-chloro-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 287°-290° C. (decomp.). Mass spectrum: m/e, 204 (P).

後処理

  1. filtrationthe solid precipitate was collected by filtration
  2. washwashed with cyclohexane
  3. customdried
  4. customto afford 8.8 g

出典と根拠

ORDレコード
ord-70b80ffed64d497681be598e3df21903
出典データセット
uspto-grants-1985_10
特許番号
US04547501

関連ノート

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