Triethyl orthoacetate → 4-Chloro-1-methyl[1,2,4]triazolo[4,3-a]quinoxaline

HRID 464281

反応式

HRID 464281 の反応式
[Cl:1][C:2]1[C:11]([NH:12][NH2:13])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:14](OCC)(OCC)(OCC)[CH3:15]>>[Cl:1][C:2]1[C:11]2[N:10]([C:14]([CH3:15])=[N:13][N:12]=2)[C:9]2[C:4]([N:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2

参加物

3

反応物 2

HCID 66221Triethyl orthoacetateHCID 36588202-Chloro-3-hydrazinoquinoxaline

生成物 1

HCID 27686434-Chloro-1-methyl[1,2,4]triazolo[4,3-a]quinoxaline収率 65%

実験手順

2-Chloro-3-hydrazinoquinoxaline (15.5 g., 0.080 mole), the product of Example 1, was stirred with triethyl orthoacetate for 3 hours at 100° C. The mixture was cooled to room temperature and the solid precipitate was collected by filtration, washed with ethanol and air dried to afford 11.4 g. (65% yield) of 4-chloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 215°-222° C. Mass spectrum: m/e, 218 (P).

後処理

  1. filtrationthe solid precipitate was collected by filtration
  2. washwashed with ethanol and air
  3. customdried
  4. customto afford 11.4 g

出典と根拠

ORDレコード
ord-4df6aa845da34ef992b18fe6e76d0aa8
出典データセット
uspto-grants-1985_10
特許番号
US04547501

関連ノート

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