Dimethylamine → 4-Dimethylamino-[1,2,4]triazolo[4,3-a]quinoxaline
反応式
Cl[C:2]1[C:3]2[N:4]([CH:12]=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:15][NH:16][CH3:17]>CN(C)C=O>[CH3:15][N:16]([CH3:17])[C:2]1[C:3]2[N:4]([CH:12]=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2参加物
4
実験手順
A slurry of 2.0 g. (0.01 mole) of 4-chloro-[1,2,4]triazolo[4,3-a]quinoxaline (the product of Example 2) in N,N-dimethylformamide (30 ml.) was saturated with dimethylamine gas and stirred at room temperature overnight. The mixture was poured over ice and the precipitate was removed by filtration. Recrystallization from ethanol gave 640 mg. (44% yield) of 4-dimethylamino-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 184°-186° C. Mass spectrum: m/e, 213 (P).
後処理
- additionThe mixture was poured over ice
- customthe precipitate was removed by filtration
- customRecrystallization from ethanol
- customgave 640 mg
出典と根拠
- ORDレコード
- ord-9b54e143db7f48f399a73e6fb77c3b07
- 出典データセット
- uspto-grants-1985_10
- 特許番号
- US04547501
反応ノート
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