Benzene, (triethoxymethyl)- → 4-Chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline

HRID 464303

反応式

HRID 464303 の反応式
[Cl:1][C:2]1[C:11]([NH:12][NH2:13])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.CCO[C:17](OCC)(OCC)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[Cl:1][C:2]1[C:11]2[N:10]([C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:13][N:12]=2)[C:9]2[C:4]([N:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2

参加物

4

反応物 2

HCID 74268Benzene, (triethoxymethyl)-HCID 36588202-Chloro-3-hydrazinoquinoxaline

生成物 1

HCID 8992904-Chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Chloro-3-hydrazinoquinoxaline (2.2 g., 0.011 mole) was mixed with 6 ml. of triethyl orthobenzoate and heated at 100° C. for 30 minutes. After cooling the orange mixture to room temperature, ethanol was added. Filtration of the resultant precipitate afforded 2.1 g. of crude product which was further purified by means of trituration with warm methanol, followed by filtration and air drying to ultimately yield 1.58 g. (51%) of pure 4-chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline as an orange solid.

後処理

  1. filtrationFiltration of the resultant precipitate
  2. customafforded 2.1 g
  3. customof crude product which was further purified by means of trituration with warm methanol
  4. filtrationfollowed by filtration and air
  5. customdrying to ultimately yield 1.58 g

出典と根拠

ORDレコード
ord-115b1a55758241a79305b5a4ab1f0ffc
出典データセット
uspto-grants-1985_10
特許番号
US04547501

関連ノート

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