Benzoyl chloride → HCID 13531099、化合物

HRID 464490ノート

反応式

HRID 464490 の反応式
[C:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([OH:18])[CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:19](OC1C=C(O)C=CC=1OC)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(N(CC)CC)C.C(Cl)(=O)C1C=CC=CC=1>CN(C)C1C=CN=CC=1.C(Cl)Cl>[C:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:11]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

7

反応物 4

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 135310983-(Benzyloxy)-4-methoxyphenolHCID 13531100HCID 13531100、化合物

生成物 1

HCID 13531099HCID 13531099、化合物

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

The compound 3-hydroxy-4-methoxyphenyl benzoate was made as follows. An amount of 2.00 gms. of 3-benzyloxy-4-methoxyphenol, 1.00 gms. of triethylamine and 0.10 gms of 4-dimethylaminopyridine were dissolved in 100ml. of methylene chloride at 0° C. and stirred. To the mixture was added 1.22 gms. of benzoyl chloride and the mixture was stirred overnight. The mixture was then washed with equal volumes of 1M hydrochloric acid, saturated sodium bicarbonate and water. The mixture was then dried over magnesium sulfate and the solvent evaporated to yield 3-benzyloxy-4-methoxyphenyl benzoate.

後処理

  1. additionTo the mixture was added 1.22 gms
  2. washThe mixture was then washed with equal volumes of 1M hydrochloric acid, saturated sodium bicarbonate and water
  3. dry with materialThe mixture was then dried over magnesium sulfate
  4. customthe solvent evaporated

出典と根拠

ORDレコード
ord-4675c0be0fd942f99df8c3bf3c5b0bff
出典データセット
uspto-grants-1985_10
特許番号
US04547584

反応ノート

読み込み中…