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Benzene, 1-bromo-3-(trifluoromethyl)- → 1-Benzhydryl-2-(m-trifluoromethylbenzimidoyl)azetidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene, 1-bromo-3-(trifluoromethyl)- | HCID 9817 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 反応物 | 1-Benzhydrylazetidine-2-carbonitrile | HCID 19772072 | — |
| 反応物 | HCID 178506173 | HCID 178506173 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-Benzhydryl-2-(m-trifluoromethylbenzimidoyl)azetidine | HCID 20387049 | — |
反応手順
Suspend m-trifluoromethylphenylmagnesium bromide in ether by adding a solution of 18 g of m-bromobenzotrifluoride in 30 ml of ether to a stirred suspension of 1.94 g of magnesium turnings in 20 ml of dry ether. Upon completion of addition, allow the reaction mixture to cool to room temperature and add 7.95 g of 1-benzhydryl-2-cyanoazetidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04173566 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-b96407d1931e4a2990162b28f74a60da |
| 出典メモ | uspto-grants-1979_11 |